Protective Immune Response of Isospora felis-Infected Mice against Babesia microti Infection.
نویسندگان
چکیده
منابع مشابه
Macrophages are critical for cross-protective immunity conferred by Babesia microti against Babesia rodhaini infection in mice.
Although primary infection of mice with Babesia microti has been shown to protect mice against subsequent lethal infection by Babesia rodhaini, the mechanism behind the cross-protection is unknown. To unravel this mechanism, we investigated the influence of primary infection of mice with nonlethal B. microti using different time courses on the outcome of subsequent lethal B. rodhaini infection....
متن کاملRoles of CD4(+) T cells and gamma interferon in protective immunity against Babesia microti infection in mice.
Babesia microti produces a self-limiting infection in mice, and recovered mice are resistant to reinfection. In the present study, the role of T cells in protective immunity against challenge infection was examined. BALB/c mice which recovered from primary infection showed strong protective immunity against challenge infection. In contrast, nude mice which failed to control the primary infectio...
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Babesia microti is a malaria-like parasite, which infects ∼2000 people annually, such that babesiosis is now a notifiable disease in the United States. Immunocompetent individuals often remain asymptomatic and are tested only after they feel ill. Susceptible C3H/HeJ mice show several human-like disease manifestations and are ideal to study pathogenesis of Babesia species. In this study, we exam...
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Infection with Babesia microti has not been well-described in eastern Pennsylvania, USA, despite the vector of this organism being prevalent. We report 3 cases of babesiosis in eastern Pennsylvania in persons without recent travel outside the region or history of blood transfusions, suggesting emergence of this infection.
متن کاملDownregulation of hepatic cytochrome P450 3A in mice infected with Babesia microti.
To investigate effects of Babesia infection on drug metabolism, we intraperitoneally inoculated B. microti into ICR mice and measured the expression and activity of hepatic cytochrome P450 (CYP) 3A, a major drug-metabolizing enzyme. Twelve days after infection, CYP3A11 mRNA, CYP3A protein and activity and mRNAs of nuclear receptors, which participate in CYP3A expression, were significantly redu...
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ژورنال
عنوان ژورنال: Journal of Veterinary Medical Science
سال: 1993
ISSN: 0916-7250,1347-7439
DOI: 10.1292/jvms.55.587